Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity
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چکیده
منابع مشابه
Chromatin and extracellular vesicle associated sperm RNAs
A diverse pool of RNAs remain encapsulated within the transcriptionally silent spermatozoon despite the dramatic reduction in cellular and nuclear volume following cytoplasm/nucleoplasm expulsion. The impact of this pronounced restructuring on the distribution of transcripts inside the sperm essentially remains unknown. To define their compartmentalization, total RNA >100 nt was extracted from ...
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Polycomb-group (PcG) proteins and associated histone modifications play pivotal roles in development, stem cell self-renewal and cancer. These proteins function in different transcriptional repressor complexes that epigenetically modify chromatin and participate in the establishment and maintenance of cell fates [1]. Although many proteins have been reported to associate with PcG protein comple...
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Evidence suggests that human sperm chromatin anomalies adversely affect reproductive outcomes and infertile men possess substantially amount of sperm with chromatin anomalies than fertile men. Routine semen analysis evaluates parameters such as sperm motility and morphology, but does not examine the nuclear DNA integrity of spermatozoa. It has been suggested that altered nuclear chromatin struc...
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Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to achieve their diverse functions. To identify these contacts, we developed a method based on RNA antisense purification to systematically map RNA-RNA interactions (RAP-RNA) and applied it to investigate two ncRNAs implicated in RNA processing: U1 small nuclear RNA, a component of the spliceosome, and Malat1, a large ...
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INTRODUCTION It is widely recognized that all that fathers essentially contribute to the next generation is half of their genome, and mature sperm cells are transcriptionally and translationally inactive. However, an increasing number of reports have shown that RNAs were present in human sperm detected by using RT-PCR, differential display, in situ hybridization and microarrays [1]. One study s...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2019
ISSN: 1559-2294,1559-2308
DOI: 10.1080/15592294.2019.1644880